Article
A role for succinate dehydrogenase genes in low chemoresponsiveness to hypoxia?
Clinical autonomic research : official journal of the Clinical Autonomic Research Society - 1 Dec 2009
Richalet Jean-Paul, Gimenez-Roqueplo Anne-Paule, Peyrard Séverine, Vénisse Annabelle, Marelle Laure, Burnichon Nelly, Bouzamondo Anissa, Jeunemaitre Xavier, Azizi Michel, Elghozi Jean-Luc
Abstract excerpt
The detection of hypoxia by the carotid bodies elicits a ventilatory response of utmost importance for tolerance to high altitude. Germline mutations in three genes encoding subunit B, C and D of succinate dehydrogenase (SDHB, SDHC and SDHD) have been associated with paragangliomas of the carotid body. We hypothesized that SDH dysfunction within the carotid body could result in low chemoresponsiveness and...
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