Article
Transforming growth factor beta and excess burden of renal disease.
Transactions of the American Clinical and Climatological Association - 1 Jan 2009
August Phyllis, Sharma Vijay, Ding Ruchuang, Schwartz Joseph E, Suthanthiran Manikkam
Abstract excerpt
End-stage renal disease (ESRD) is more frequent in African Americans (blacks) compared to whites. Because renal fibrosis is a correlate of progressive renal failure and a dominant feature of ESRD, and because transforming growth factor beta 1 (TGF-beta1) can induce fibrosis and renal insufficiency, we hypothesized that TGF-beta1 hyperexpression is more frequent in blacks compared to whites. We measured...
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