Article
A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n.
Nature - 30 Aug 1990
Wilkie A O, Lamb J, Harris P C, Finney R D, Higgs D R
Abstract excerpt
The instability of chromosomes with breaks induced by X-irradiation led to the proposal that the natural ends of chromosomes are capped by a specialized structure, the telomere. Telomeres prevent end-to-end fusions and exonucleolytic degradation, enable the end of the linear DNA molecule to replicate, and function in cell division. Human telomeric DNA comprises approximately 2-20 kilobases (kb) of the tandemly...
Topics
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 16
- Endodeoxyribonucleases
- Genotype
- Globins
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization