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Article

A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n.

Nature - 30 Aug 1990

Wilkie A O, Lamb J, Harris P C, Finney R D, Higgs D R

Abstract excerpt

The instability of chromosomes with breaks induced by X-irradiation led to the proposal that the natural ends of chromosomes are capped by a specialized structure, the telomere. Telomeres prevent end-to-end fusions and exonucleolytic degradation, enable the end of the linear DNA molecule to replicate, and function in cell division. Human telomeric DNA comprises approximately 2-20 kilobases (kb) of the tandemly...

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Identifiers

PMID: 1975428
DOI: 10.1038/346868a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n.PMID 1975428Read ↗

Chromosomal stabilisation by a subtelomeric rearrangement involving two closely related Alu elements.Semantic proximity Read ↗

The plasticity of human telomeres demonstrated by a hypervariable telomere repeat array that is located on some copies of 16p and 16q.Semantic proximity Read ↗

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.Semantic proximity Read ↗

Alpha-thalassaemia.Semantic proximity Read ↗

Recognition of a chromosome truncation site associated with α-thalassaemia by human telomeraseSemantic proximity Read ↗

An unusually large (CA)n repeat in the region of divergence between subtelomeric alleles of human chromosome 16p.Semantic proximity Read ↗

Human alpha-globin gene expression is silenced by terminal truncation of chromosome 16p beginning immediately 3' of the zeta-globin gene.Semantic proximity Read ↗

Structure and Variability of Human Chromosome EndsSemantic proximity Read ↗

Types, stability, and phenotypic consequences of chromosome rearrangements leading to interstitial telomeric sequences.Semantic proximity Read ↗

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