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Article

Types, stability, and phenotypic consequences of chromosome rearrangements leading to interstitial telomeric sequences.

Journal of medical genetics - 1 Nov 1993

Rossi E, Floridia G, Casali M, Danesino C, Chiumello G, Bernardi F, Magnani I, Papi L, Mura M, Zuffardi O

Abstract excerpt

Using in situ hybridisation, we identified interstitial telomeric sequences in seven chromosomal translocations present in normal and in syndromic subjects. Telomeric sequences were also found at the centromeric ends of a 4p and a 4q caused by centric fission of one chromosome 4. We found that rearrangements leading to interstitial telomeric sequences were of three types: (1) termino-terminal rearrangements with...

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Identifiers

PMID: 8301647
DOI: 10.1136/jmg.30.11.926
PMCID: PMC1016601

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