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Light-Independent Metabolomics of Endophytic <i>Thielavia subthermophila</i> Provides Insight into Microbial Hypericin Biosynthesis

11 Sept 2009

Abstract excerpt

The possible microbial mechanism of hypericin (1) and emodin (2) biosynthesis was studied in axenic submerged culture conditions in the endophytic fungus Thielavia subthermophila, isolated from Hypericum perforatum. The growth and secondary metabolite production of the endophyte remained independent of the illumination conditions. This production remained unaltered on spiking the medium with 3 or 5 mM 2, although...

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PMID: 19746917
DOI: 10.1021/np9002977

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