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Article

Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant.

British journal of clinical pharmacology - 1 Sept 2009

Hawwa Ahmed F, McKiernan Patrick J, Shields Michael, Millership Jeff S, Collier Paul S, McElnay James C

Abstract excerpt

AIMS: The aim of this study was to investigate the influence of genetic polymorphisms in ABCB1 on the incidence of nephrotoxicity and tacrolimus dosage-requirements in paediatric patients following liver transplantation. METHODS: Fifty-one paediatric liver transplant recipients receiving tacrolimus were genotyped for ABCB1 C1236>T, G2677>T and C3435>T polymorphisms. Dose-adjusted tacrolimus trough concentrations...

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Source

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Identifiers

PMID: 19740399
DOI: 10.1111/j.1365-2125.2009.03461.x
PMCID: PMC2766481

Genes

ABCB1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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