Article
Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation.
Genetics - 1 Nov 2009
Xue Yali, Zhang Xuelong, Huang Ni, Daly Allan, Gillson Christopher J, Macarthur Daniel G, Yngvadottir Bryndis, Nica Alexandra C, Woodwark Cara, Chen Yuan, Conrad Donald F, Ayub Qasim, Mehdi S Qasim, Li Pu, Tyler-Smith Chris
Abstract excerpt
We have evaluated the extent to which SNPs identified by genomewide surveys as showing unusually high levels of population differentiation in humans have experienced recent positive selection, starting from a set of 32 nonsynonymous SNPs in 27 genes highlighted by the HapMap1 project. These SNPs were genotyped again in the HapMap samples and in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme...
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