Article
Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.
Genome biology - 30 Jun 2014
Colonna Vincenza, Ayub Qasim, Chen Yuan, Pagani Luca, Luisi Pierre, Pybus Marc, Garrison Erik, Xue Yali, Tyler-Smith Chris, Abecasis Goncalo R, Auton Adam, Brooks Lisa D, DePristo Mark A, Durbin Richard M, Handsaker Robert E, Kang Hyun Min, Marth Gabor T, McVean Gil A
Abstract excerpt
BACKGROUND: Population differentiation has proved to be effective for identifying loci under geographically localized positive selection, and has the potential to identify loci subject to balancing selection. We have previously investigated the pattern of genetic differentiation among human populations at 36.8 million genomic variants to identify sites in the genome showing high frequency differences. Here, we...
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