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Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging

3 Sept 2009

Abstract excerpt

Generations of biogerontologists have been puzzled by the marked intraspecific variations in lifespan of their experimental model organisms despite all efforts to control both genotype and environment. The most cogent example comes from life table studies of wild-type Caenorhabditis elegans when grown in suspension cultures using axenic media. While nuclear and mitochondrial somatic mutations and 'thermodynamic...

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PMID: 19732045
DOI: 10.1111/j.1474-9726.2009.00515.x

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