Article
Inference of antibiotic resistance and virulence among diverse group A Streptococcus strains using emm sequencing and multilocus genotyping methods.
PloS one - 4 Sept 2009
Metzgar David, Baynes Darcie, Hansen Christian J, McDonough Erin A, Cabrera Daisy R, Ellorin Melody M, Blair Patrick J, Russell Kevin L, Faix Dennis J
Abstract excerpt
BACKGROUND: Group A Streptococcus pyogenes (GAS) exhibits a high degree of clinically relevant phenotypic diversity. Strains vary widely in terms of antibiotic resistance (AbR), clinical severity, and transmission rate. Currently, strain identification is achieved by emm typing (direct sequencing of the genomic segment coding for the antigenic portion of the M protein) or by multilocus genotyping methods....
Topics
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Bacterial Typing Techniques
- Carrier Proteins
- Drug Resistance, Bacterial
- Genetic Techniques
- Genotype
- Humans
- Phenotype
- Polymerase Chain Reaction
- Reproducibility of Results
- Sequence Analysis, DNA