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Article

Estrogen receptor-alpha gene (T/C) Pvu II polymorphism in endometriosis and uterine fibroids.

Disease markers - 1 Jan 2009

Govindan Sujatha, Shaik Noor Ahmad, Vedicherla Bhavani, Kodati Vijayalakshmi, Rao Kaipa Prabhakar, Hasan Qurratulain

Abstract excerpt

Endometriosis and fibroids are estrogen-dependent benign pathologies of the uterus, which account for infertility and pelvic pain along with dysmenorrhea in women. Suppression of the disease and recurrence after discontinuing hormone therapy strongly suggests that these are responsive to hormones, especially estrogen, which acts via its receptor. A T/C SNP in intron 1 and exon 2 boundary of estrogen receptor (ER)...

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Identifiers

PMID: 19729795
DOI: 10.3233/DMA-2009-0625
PMCID: PMC3833240

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