Article
Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Dec 2009
De Kock Joery, Vanhaecke Tamara, Biernaskie Jeffrey, Rogiers Vera, Snykers Sarah
Abstract excerpt
In the present study, we investigated whether precursor cells isolated from the dermis of infant human foreskin are capable to differentiate into hepatocyte-like cells upon sequential and gradual exposure to hepatogenic factors [fibroblast growth factor (FGF)-4, hepatocyte growth factor (HGF), insulin-transferrin-selenite (ITS), dexamethasone and oncostatin M (OSM)], mimicking the liver embryogenesis in vivo....
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