Article
Transitions at CpG dinucleotides, geographic clustering of TP53 mutations and food availability patterns in colorectal cancer.
PloS one - 31 Aug 2009
Verginelli Fabio, Bishehsari Faraz, Napolitano Francesco, Mahdavinia Mahboobeh, Cama Alessandro, Malekzadeh Reza, Miele Gennaro, Raiconi Giancarlo, Tagliaferri Roberto, Mariani-Costantini Renato
Abstract excerpt
BACKGROUND: Colorectal cancer is mainly attributed to diet, but the role exerted by foods remains unclear because involved factors are extremely complex. Geography substantially impacts on foods. Correlations between international variation in colorectal cancer-associated mutation patterns and food availabilities could highlight the influence of foods on colorectal mutagenesis. METHODOLOGY: To test such...
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