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Article

Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota.

The Journal of investigative dermatology - 1 Oct 2009

Scharschmidt Tiffany C, List Karin, Grice Elizabeth A, Szabo Roman, Renaud Gabriel, Lee Chyi-Chia R, Wolfsberg Tyra G, Bugge Thomas H, Segre Julia A

Abstract excerpt

Suppressor of tumorigenicity 14 (St14) encodes matriptase, a serine protease, which regulates processing of profilaggrin to filaggin in vivo. Here, we report that transgenic mice with 1% of wild-type St14 levels (St14(hypo/-)) display aberrant processing of profilaggrin and model human ichthyotic...

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Source

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Identifiers

PMID: 19387477
DOI: 10.1038/jid.2009.104
PMCID: PMC2791707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19387477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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