Article
Association of angiotensin-converting enzyme gene promoter single nucleotide polymorphisms and haplotype with major depression in a northeastern Thai population.
Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Sept 2009
Angunsri Rudee, Sritharathikhun Thapanut, Suttirat Sarawut, Tencomnao Tewin
Abstract excerpt
INTRODUCTION: Angiotensin-converting enzyme (ACE) is thought to influence the activity of the hypothalamic-pituitary-adrenocortical system, which shows hyperactivity in the majority of patients with major depressive disorder (MDD). This study aimed at determining an association between two single nucleotide polymorphisms (SNPs) (rs4291;-240A/T and rs4292;-93T/C) of the ACE gene promoter and MDD in northeastern...
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