Article
Status of PI3K inhibition and biomarker development in cancer therapeutics.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2010
Markman B, Atzori F, Pérez-García J, Tabernero J, Baselga J
Abstract excerpt
The phosphatidylinositol 3-kinase (PI3K) signalling pathway is integral to diverse cellular functions, including cellular proliferation, differentiation and survival. The 'phosphate and tensin homologue deleted from chromosome 10' (PTEN) tumor suppressor gene plays a critical role as a negative regulator of this pathway. An array of genetic mutations and amplifications has been described affecting key components...
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