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Article

EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer.

Human pathology - 1 Dec 2018

Birkman Eva-Maria, Avoranta Tuulia, Ålgars Annika, Korkeila Eija, Lintunen Minnamaija, Lahtinen Laura, Kuopio Teijo, Ristamäki Raija, Carpén Olli, Sundström Jari

Abstract excerpt

Epidermal growth factor receptor (EGFR) gene copy number (GCN) increase is associated with a favorable anti-EGFR antibody treatment response in RAS wild-type metastatic colorectal cancer. However, there are limited and comparative data regarding the EGFR GCN in primary colorectal cancer tumors and corresponding metastases or the effect of anti-EGFR antibody treatment on EGFR GCN in recurrent disease. In addition,...

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Source

Identifiers

PMID: 30096327
DOI: 10.1016/j.humpath.2018.07.028

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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