Article
Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations.
Molecular diagnosis & therapy - 1 Jun 2014
Maeda Hiromichi, Hazama Shoichi, Shavkat Abdiev, Okamoto Ken, Oba Koji, Sakamoto Junichi, Takahashi Kenichi, Oka Masaki, Nakamura Daisuke, Tsunedomi Ryouichi, Okayama Naoko, Mishima Hideyuki, Kobayashi Michiya
Abstract excerpt
BACKGROUND AND OBJECTIVES: Uridine-diphosphate glucuronosyltransferase 1A (UGT1A) is a key enzyme involved in irinotecan metabolism, and polymorphisms in the UGT1A gene are associated with irinotecan-induced toxicity. The aim of this study was to elucidate the allele frequencies of UGT1A polymorphisms in healthy Uzbek volunteers, and to compare them with those of the Japanese population. METHOD: A total of 97...
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