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Article

Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.

Journal of virology - 1 Nov 2009

Martínez-Sobrido Luis, Emonet Sébastien, Giannakas Panagiotis, Cubitt Beatrice, García-Sastre Adolfo, de la Torre Juan C

Abstract excerpt

Lymphocytic choriomeningitis virus (LCVM) nucleoprotein (NP) counteracts the host type I interferon (IFN) response by inhibiting activation of the IFN regulatory factor 3 (IRF3). In this study, we have mapped the regions and specific amino acid residues within NP involved in its anti-IFN activity...

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Source

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Identifiers

PMID: 19710144
DOI: 10.1128/JVI.00763-09
PMCID: PMC2772779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19710144-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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