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Article

MicroRNA-1/206 Targets c-Met and Inhibits Rhabdomyosarcoma Development

27 Aug 2009

Abstract excerpt

MicroRNAs (miRNAs) are endogenous short (approximately 22) nucleotide RNAs that regulate gene function by modification of target mRNAs. miRNA-1 (miR-1) and miRNA-206 (miR-206) are highly expressed in skeletal muscle. Due to the tissue-specific nature of miR-1/206 for skeletal muscles, we investigated the role of miR-1/206 in the development of rhabdomyosarcoma. Initially, we demonstrated that miR-1/206 expression...

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PMID: 19710019
DOI: 10.1074/jbc.m109.020511

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