Article
[Analysis of mitochondrial 12S rRNA and tRNA(Ser(UCN)) genes in patients with nonsyndromic sensorineural hearing loss from various regions of Russia].
Genetika - 1 Jul 2009
Dzhemileva L U, Posukh O L, Tazetdinov A M, Barashkov N A, Zhuravskiĭ S G, Ponidelko S N, Markova T G, Tadinova V N, Fedorova S A, Maksimova N R, Khusnutdinova E K
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations play an important role in etiology of hereditary hearing loss. In various regions of the world, patients suffer from nonsyndromic sensorineural hearing loss initiated by aminoglycoside antibiotics. Mutations that had been shown as pathogenetically important for hearing function disturbance were identified in mitochondrial 12S rRNA and tRNA(Ser(UCN)) genes while pathogenic role...
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