Malignant hyperthermia--a large kindred linked to the RYR1 gene.

doi:10.1111/j.1365-2044.1996.tb07647.x

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Article

Malignant hyperthermia--a large kindred linked to the RYR1 gene.

Anaesthesia - 1 Jan 1996

Wallace A J, Wooldridge W, Kingston H M, Harrison M J, Ellis F R, Ford P M

Abstract excerpt

Malignant hyperthermia susceptibility is genetically heterogeneous. The ryanodine receptor gene on the long arm of chromosome 19 represents an important candidate gene but not all families with malignant hyperthermia demonstrate ryanodine receptor mutations or linkage to this region of 19q. Linka...

Topics

Calcium Channels
Chromosome Mapping
Chromosomes, Human, Pair 19
Creatine Kinase
Female
Genes
Genetic Linkage
Genetic Predisposition to Disease
Humans
Male
Malignant Hyperthermia
Muscle Proteins
Pedigree
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid
Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed

Identifiers

PMID: 8669559
DOI: 10.1111/j.1365-2044.1996.tb07647.x

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8669559-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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