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Article

Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations.

European journal of clinical investigation - 1 Nov 2009

Calado R T, Regal J A, Kajigaya S, Young N S

Abstract excerpt

BACKGROUND: Loss-of-function mutations in telomerase complex genes reduce telomerase activity and shorten overall telomere length in leucocytes, and they can clinically manifest as bone marrow failure (aplastic anaemia and dyskeratosis congenita) and familial pulmonary fibrosis. Telomeres are constituted of double-stranded tandem TTAGGG repeats followed by a 3' G-rich single-stranded overhang, a crucial telomeric...

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Identifiers

PMID: 19674077
DOI: 10.1111/j.1365-2362.2009.02209.x
PMCID: PMC6738339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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