Article
Diminished telomeric 3' overhangs are associated with telomere dysfunction in Hoyeraal-Hreidarsson syndrome.
PloS one - 22 May 2009
Lamm Noa, Ordan Elly, Shponkin Rotem, Richler Carmelit, Aker Memet, Tzfati Yehuda
Abstract excerpt
BACKGROUND: Eukaryotic chromosomes end with telomeres, which in most organisms are composed of tandem DNA repeats associated with telomeric proteins. These DNA repeats are synthesized by the enzyme telomerase, whose activity in most human tissues is tightly regulated, leading to gradual telomere shortening with cell divisions. Shortening beyond a critical length causes telomere uncapping, manifested by the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.