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Article

Telomere elongation and clinical response to androgen treatment in a patient with aplastic anemia and a heterozygous hTERT gene mutation.

Annals of hematology - 1 Jul 2012

Ziegler Patrick, Schrezenmeier Hubert, Akkad Jamil, Brassat Ute, Vankann Lucia, Panse Jens, Wilop Stefan, Balabanov Stefan, Schwarz Klaus, Martens Uwe M, Brümmendorf Tim H

Abstract excerpt

Telomere length (TL) both reflects and limits the replicative life span of normal somatic cells. As a consequence, critically shortened telomeres are associated with a variety of disease states. Telomere attrition can be counteracted by a nucleoprotein complex containing telomerase. Mutations in subunits of telomerase, telomerase-binding proteins as well as in members of the shelterin complex have been described...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22476886
DOI: 10.1007/s00277-012-1454-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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