Article
Adenoma development in a patient with MUTYH-associated polyposis (MAP): new insights into the natural course of polyp development.
Digestive diseases and sciences - 1 Jun 2010
Casper Markus, Plotz Guido, Juengling Bernhard, Trojan Joerg, Lammert Frank, Raedle Jochen
Abstract excerpt
PURPOSE: Biallelic germ-line mutations in MUTYH have recently been found to predispose for MUTYH-associated polyposis (MAP). Affected patients present with a wide range of clinical phenotypes at the time of diagnosis, but there is little precise information about the natural course of this disease. RESULTS: Fourteen years of colonoscopic surveillance of an MAP patient (compound heterozygous p.Y165C/p.G382D)...
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