Article
Beta-thalassemia genes in French-Canadians: haplotype and mutation analysis of Portneuf chromosomes.
American journal of human genetics - 1 Jan 1990
Kaplan F, Kokotsis G, DeBraekeleer M, Morgan K, Scriver C R
Abstract excerpt
beta-Thalassemia minor occurs at approximately 1% frequency in French-Canadians--in families residing in Portneuf County (population approximately 40,000) of Quebec province. We found eight different RFLP haplotypes at the beta-globin gene cluster in 37 normal persons and in 12 beta-thalassemia heterozygotes from six families. beta-Thalassemia genes in these families associated with two haplotypes only:...
Topics
- DNA Mutational Analysis
- DNA Probes
- France
- Genetic Linkage
- Genetic Markers
- Genetics, Population
- Globins
- Haplotypes
- Humans
- Mutation
- Polymorphism, Restriction Fragment Length