Article
Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice.
Genes, brain, and behavior - 1 Oct 2009
Foreman J E, Lionikas A, Lang D H, Gyekis J P, Krishnan M, Sharkey N A, Gerhard G S, Grant M D, Vogler G P, Mack H A, Stout J T, Griffith J W, Lakoski J M, Hofer S M, McClearn G E, Vandenbergh D J, Blizard D A
Abstract excerpt
A quantitative trait locus (QTL) analysis of behaviors across the life span was conducted in F(2) mice from a C57BL/6J x DBA/2J cross and 22 BXD recombinant inbred (RI) strains. Mice of three age groups were tested in a hole-board apparatus for 3 min on three occasions approximately 1 month apart (average age at test 150, 450 and 750 days, approximately 400 mice per group, divided equally by sex). Quantitative...
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