Article
Clinical significance of EML4-ALK fusion gene and association with EGFR and KRAS gene mutations in 208 Chinese patients with non-small cell lung cancer.
PloS one - 1 Jan 2013
Li Ying, Li Yongwen, Yang Tong, Wei Sen, Wang Jing, Wang Min, Wang Yuli, Zhou Qinghua, Liu Hongyu, Chen Jun
Abstract excerpt
The EML4-ALK fusion gene has been recently identified in a small subset of non-small cell lung cancer (NSCLC) patients who respond positively to ALK inhibitors. The characteristics of the EML4-ALK fusion gene in Chinese patients with NSCLC are poorly understood. Here, we report on the prevalence of EML4-ALK, EGFR status and KRAS mutations in 208 Chinese patients with NSCLC. EGFR mutations were found in 24.5%...
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