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Article

N-acetyltransferase 1 and 2 polymorphisms in para-substituted arylamine-induced contact allergy.

The British journal of dermatology - 1 Jun 2000

Westphal G A, Reich K, Schulz T G, Neumann C, Hallier E, Schnuch A

Abstract excerpt

Sensitization to arylamines such as p-phenylenediamine is frequently diagnosed in patients with allergic contact dermatitis. Reactive metabolites of p-phenylenediamine might be produced in the skin by O-acetylation of N-hydroxylamines catalysed by local N-acetyltransferases (NATs). In this study, we tested whether genetic polymorphisms of NATs, which are known to affect enzyme activity, may influence the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10848734
DOI: 10.1046/j.1365-2133.2000.03536.x

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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