Article
Expression of cochlin mRNA splice variants in the inner ear.
Audiology & neuro-otology - 1 Jan 2010
Sekine Kuwon, Ikezono Tetsuo, Matsumura Tomohiro, Shindo Susumu, Watanabe Atsushi, Li Lishu, Pawankar Ruby, Nishino Takeshi, Yagi Toshiaki
Abstract excerpt
Proteomic analysis of inner ear proteins revealed unique properties of cochlin, encoded by the COCH gene. We detected 3 cochlin isoforms, p63s, p44s and p40s, in the inner ear tissue and a short 16-kDa isoform, cochlin-tomoprotein (CTP), in the perilymph. The role of the cochlin isoforms has not been elucidated. To improve our understanding of the mechanism of cochlin isoform expression, we investigated rat...
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