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Article

Expression of cochlin in the vestibular organ of rats.

ORL; journal for oto-rhino-laryngology and its related specialties - 1 Jan 2005

Ikezono Tetsuo, Shindo Susumu, Ishizaki Masamichi, Li Lishu, Tomiyama Shunichi, Takumida Masaya, Pawankar Ruby, Watanabe Atsushi, Saito Akihiko, Yagi Toshiaki

Abstract excerpt

The COCH gene mutated in autosomal dominant sensorineural deafness (DFNA9) encodes cochlin, a major constituent of the inner ear extracellular matrix. Cochlin constitutes 70% of the inner ear protein and cochlin isoforms can be classified into three subgroups, p63s, p44s and p40s. Symptoms of some DFNA9 patients are consistent with those of Ménière's disease. Here, we report the expression of cochlin in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16374056
DOI: 10.1159/000089404

Genes

COCH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of cochlin in the vestibular organ of rats.PMID 16374056Read ↗

On the pathophysiology of DFNA9: Effect of pathogenic variants in the COCH gene on inner ear functioning in human and transgenic mice.Semantic proximity Read ↗

Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9.Semantic proximity Read ↗

Expression of full-length Cochlin p63s is inner ear specific.Semantic proximity Read ↗

Identification of a novel Cochlin isoform in the perilymph: insights to Cochlin function and the pathogenesis of DFNA9.Semantic proximity Read ↗

Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunction.Semantic proximity Read ↗

Histopathology of the Human Inner Ear in the p.L114P COCH Mutation (DFNA9).Semantic proximity Read ↗

DFNA9 is a progressive audiovestibular dysfunction with a microfibrillar deposit in the inner ear.Semantic proximity Read ↗

Expression of cochlin mRNA splice variants in the inner ear.Semantic proximity Read ↗

Mutations in COCH that result in non-syndromic autosomal dominant deafness (DFNA9) affect matrix deposition of cochlin.Semantic proximity Read ↗

A study of whirlin isoforms in the mouse vestibular system suggests potential vestibular dysfunction in DFNB31-deficient patients.Semantic proximity Read ↗

Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Meniere's disease.Semantic proximity Read ↗

Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor.Semantic proximity Read ↗

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