Article
Expression of full-length Cochlin p63s is inner ear specific.
Auris, nasus, larynx - 1 Sept 2005
Li Lishu, Ikezono Tetsuo, Watanabe Atsushi, Shindo Susumu, Pawankar Ruby, Yagi Toshiaki
Abstract excerpt
OBJECTIVE: The COCH gene mutated in DFNA9, murine an autosomal dominant hereditary hearing impairment, encodes Cochlin. Cochlin is also suggested to be the self-antigen of autoimmune sensorineural hearing loss. We previously reported that Cochlin constitutes 70% of the inner ear proteins and is classified into three types of isoform, p63s, p44s, and p40s. To study the specificity of expression of Cochlin isoforms...
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