Article
Positive selection and gene conversion drive the evolution of a brain-expressed snoRNAs cluster.
Molecular biology and evolution - 1 Nov 2009
Ogorelkova Miroslava, Navarro Arcadi, Vivarelli Francesca, Ramirez-Soriano Anna, Estivill Xavier
Abstract excerpt
HBII-52 small nucleolar RNAs (snoRNAs) are brain-expressed posttranscriptional modifiers of serotonin receptor 2C RNA. They are organized in a cluster of 47 highly homologous gene copies spanning 100 kb at chromosome 15q11.2. Nucleotide diversity at HBII-52 snoRNA gene cluster in African and European descent populations was analyzed via resequencing of 25 functional snoRNA gene copies. Ninety-four variants were...
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