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Article

Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation.

Journal of cellular physiology - 1 Nov 2009

Hoeppner Luke H, Secreto Frank, Jensen Eric D, Li Xiaodong, Kahler Rachel A, Westendorf Jennifer J

Abstract excerpt

Lymphoid Enhancer Binding Factor (Lef) 1 is a transcriptional effector of the Wnt/Lrp5/beta-catenin signaling cascade, which regulates osteoblast differentiation, bone density, and skeletal strength. In this study, we describe the expression and function of an alternative Lef1 isoform in osseous...

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Source

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Identifiers

PMID: 19650108
DOI: 10.1002/jcp.21879
PMCID: PMC3874810

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19650108-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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