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Article

Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish.

Journal of neurobiology - 1 Apr 2006

Ninkovic Jovica, Folchert Anja, Makhankov Yuri V, Neuhauss Stephan C F, Sillaber Inge, Straehle Uwe, Bally-Cuif Laure

Abstract excerpt

Addiction is a complex maladaptive behavior involving alterations in several neurotransmitter networks. In mammals, psychostimulants trigger elevated extracellular levels of dopamine, which can be modulated by central cholinergic transmission. Which elements of the cholinergic system might be targeted for drug addiction therapies remains unknown. The rewarding properties of drugs of abuse are central for the...

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Source

Identifiers

PMID: 16470869
DOI: 10.1002/neu.20231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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