Article
Gene dosage effect in acquired monosomy 7: distinct behaviour of beta-glucuronidase and phosphoserine phosphatase.
Genes, chromosomes & cancer - 1 Jan 1990
Minelli A, Piantanida M, Maserati E, Campagnoli E, Pasquali F, Danesino C
Abstract excerpt
Evidence for gene dosage effect for beta-glucuronidase (GUSB) and phosphoserine phosphatase (PSP), whose genes are mapped on chromosome 7, was searched in a group of 13 patients with myeloproliferative disorders and acquired monosomy 7. The monosomy 7 was the sole anomaly in nine patients and was...
Topics
- Alleles
- Anemia, Refractory, with Excess of Blasts
- Blast Crisis
- Chromosomes, Human, Pair 7
- Enzyme Induction
- Gene Expression Regulation, Neoplastic
- Genetic Markers
- Glucuronidase
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Acute
- Leukemia, Myelomonocytic, Chronic
- Monosomy
- Neoplasm Proteins
- Phosphoric Monoester Hydrolases