Article
De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis.
Hepatology (Baltimore, Md.) - 1 Aug 2009
Keitel Verena, Burdelski Martin, Vojnisek Zsuzsanna, Schmitt Lutz, Häussinger Dieter, Kubitz Ralf
Abstract excerpt
Progressive familial intrahepatic cholestasis type 2 (PFIC-2) is caused by mutations of the bile salt export pump (BSEP [ABCB11]), an ATP-binding cassette (ABC)-transporter exclusively expressed at the canalicular membrane of hepatocytes. An absence of BSEP from the canalicular membrane causes cholestasis and leads to liver cirrhosis, which may necessitate liver transplantation in early childhood. We report on...
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