Article
Rituximab as therapy for the recurrence of bile salt export pump deficiency after liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Dec 2013
Lin Henry C, Alvarez Luis, Laroche Greggy, Melin-Aldana Hector, Pfeifer Kim, Schwarz Kathleen, Whitington Peter F, Alonso Estella M, Ekong Udeme D
Abstract excerpt
Progressive familial intrahepatic cholestasis type 2 (PFIC2) results from recessive mutations in the adenosine triphosphate-binding cassette B11 gene, which encodes for bile salt export pump (BSEP). Liver transplantation (LT) is offered to PFIC2 patients with end-stage liver disease. Reports have described recurrent cholestasis in PFIC2 patients after transplantation, and this has been associated with...
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