Article
High affinity anti-BSEP antibodies after liver transplantation for PFIC-2 - Successful treatment with immunoadsorption and B-cell depletion.
Pediatric transplantation - 1 Nov 2016
Kubitz Ralf, Dröge Carola, Kluge Stefanie, Stindt Jan, Stross Claudia, Häussinger Dieter, Flechtenmacher Christa, Wenning Daniel, Teufel Ulrike, Schmitt Claus Peter, Engelmann Guido
Abstract excerpt
PFIC due to BSEP mutations (PFIC type 2) often necessitates OLT. It has recently been recognized that some PFIC-2 patients develop phenotypic disease recurrence post-OLT due to the appearance of anti-BSEP antibodies. Here, we describe a boy who became cholestatic four yr after OLT during modification of immunosuppression. Canalicular antibody deposits were detected in biopsies of the transplant and antibodies...
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