Article
Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation.
International journal of obesity (2005) - 1 Oct 2009
Brandstätter A, Lingenhel A, Zwiauer K, Strobl W, Kronenberg F
Abstract excerpt
BACKGROUND: Lipoprotein(a) [Lp(a)] is considered an independent risk factor for cardiovascular disease. Its concentration is mainly determined by the kringle-IV repeat copy number variation (CNV) at the apolipoprotein(a) [apo(a)] locus. OBJECTIVE: We aimed to investigate the immediate effect of weight reduction on plasma Lp(a) levels and its dependency on the apo(a) CNV in obese children. DESIGN: We performed a...
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