Article
Fine-mapping of candidate region in Amish and Ashkenazi families confirms linkage of refractive error to a QTL on 1p34-p36.
Molecular vision - 17 Jul 2009
Wojciechowski Robert, Bailey-Wilson Joan E, Stambolian Dwight
Abstract excerpt
PURPOSE: A previous genome-wide study in Orthodox Ashkenazi Jewish pedigrees showed significant linkage of ocular refraction to a Quantitative Trait Locus (QTL) on 1p34-36.1. We carried out a fine-mapping study of this region in Orthodox Ashkenazi Jewish (ASHK) and Old Order Amish (OOA) families to confirm linkage and narrow the candidate region. METHODS: Families were recruited from ASHK and OOA American...
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