Functional analysis of the C-reactive protein (CRP) gene -717A>G polymorphism associated with coronary heart disease.

doi:10.1186/1471-2350-10-73

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Article

Functional analysis of the C-reactive protein (CRP) gene -717A>G polymorphism associated with coronary heart disease.

BMC medical genetics - 22 Jul 2009

Wang Laiyuan, Lu Xiangfeng, Li Yun, Li Hongfan, Chen Shufeng, Gu Dongfeng

Abstract excerpt

BACKGROUND: Atherosclerosis underlies the major pathophysiological mechanisms of coronary heart disease (CHD), and inflammation contributes to all phases of atherosclerosis. C-reactive protein (CRP), a sensitive, but nonspecific marker of inflammation has been shown to play proatherogenic roles in the process of atherosclerosis. Our previous report showed that rs2794521 (-717A>G), located in the promoter of the...

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PMID: 19624831
DOI: 10.1186/1471-2350-10-73
PMCID: PMC2723087

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