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Article

Regulation of alkyl-dihydrothiazole-carboxylates (ATCs) by iron and the pyochelin gene cluster in Pseudomonas aeruginosa.

ACS chemical biology - 21 Aug 2009

Vinayavekhin Nawaporn, Saghatelian Alan

Abstract excerpt

Using the pyochelin (pch) gene cluster as an example, we demonstrate the utility of untargeted metabolomics in the discovery and characterization of secondary metabolites regulated by biosynthetic gene clusters. Comparison of the extracellular metabolomes of pch gene cluster mutants to the wild-type Pseudomonas aeruginosa (strain PA 14) identified 198 ions regulated by the pch genes. In addition to known...

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PMID: 19621937
DOI: 10.1021/cb900075n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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