Article
Mathematical modeling of the capillary-like pattern generated by adrenomedullin-treated human vascular endothelial cells in vitro.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2009
Guidolin Diego, Albertin Giovanna, Sorato Elisa, Oselladore Barbara, Mascarin Alessandra, Ribatti Domenico
Abstract excerpt
A recently proposed approach was used to model the self-organization into capillary-like structures of human vascular endothelial cells cultured on Matrigel. The model combines a Cellular Potts Model, considering cell adhesion, cytoskeletal rearrangement and chemotaxis, and a Partial Differential Equation model describing the release and the diffusion of a chemoattractant. The results were compared with the data...
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