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Article

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009

Wang Hongyan, Wei Bin, Bismuth Georges, Rudd Christopher E

Abstract excerpt

Although adaptor ADAP (FYB) and its binding to SLP-76 has been implicated in TcR-induced "inside-out" signaling for LFA-1 activation in T cells, little is known regarding its role in LFA-1-mediated "outside-in" signaling. In this study, we demonstrate that ADAP and SLP-76-ADAP binding are coupled...

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Identifiers

PMID: 19617540
DOI: 10.1073/pnas.0900510106
PMCID: PMC2710989

Genes

ICAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19617540-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.PMID 19617540Read ↗

The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76.Semantic proximity Read ↗

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.Semantic proximity Read ↗

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HPK1 competes with ADAP for SLP‐76 binding and <i>via</i> Rap1 negatively affects T‐cell adhesionSemantic proximity Read ↗

The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.Semantic proximity Read ↗

Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.Semantic proximity Read ↗

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Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion.Semantic proximity Read ↗

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Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF.Semantic proximity Read ↗

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