Article
HbA2-Partinico or delta(A2)Pro-->Thr, a new genetic variation in the delta-globin gene in cis to the beta(+) thal IVS-I-110 G>A, and the heterogeneity of delta-globin alleles in double heterozygotes for beta- and delta-globin gene defects.
Annals of hematology - 1 Feb 2010
Lacerra Giuseppina, Scarano Clelia, Musollino Gennaro, Testa Rosario, Prezioso Romeo, Caruso Daniela G, Lagona Laura F, Medulla Emilia, Friscia Maria G, Gaudiano Carlo, Carestia Clementina
Abstract excerpt
The study of the alleles of the delta-globin gene is relevant to the prevention of beta-thalassemia homozygosis; in fact, the increase of the HbA2 is an invaluable hematological marker of the beta-thalassemia heterozygosis and the double heterozygosis for alleles of delta- and beta-globin genes can cause the decrease of the HbA2 up to normal or borderline values. We carried out the characterization of alleles of...
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