Alpha 1-antitrypsin deficiency, complement activation, and chronic liver disease.

doi:10.1136/jcp.44.10.855

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Article

Alpha 1-antitrypsin deficiency, complement activation, and chronic liver disease.

Journal of clinical pathology - 1 Oct 1991

Littleton E T, Bevis L, Hansen L J, Peakman M, Mowat A P, Mieli-Vergani G, Vergani D

Abstract excerpt

Activation of the complement system, the main humoral mediator of inflammation, is restrained by the action of enzyme inhibitors including alpha 1-antitrypsin. Deficiency leads to chronic liver disease in about one in five children with this genetic defect. Complement activation was investigated...

Topics

Adolescent
Child
Child, Preschool
Chronic Disease
Complement Activation
Complement C3
Complement C3d
Complement C4
Female
Humans
Infant
Liver Diseases
Male
Phenotype
alpha 1-Antitrypsin Deficiency

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