Article
Independent and combined influence of AGTR1 variants and aerobic exercise on oxidative stress in hypertensives.
Blood pressure - 1 Jan 2009
Fenty-Stewart Nicola, Park Joon-Young, Roth Stephen M, Hagberg James M, Basu Samar, Ferrell Robert E, Brown Michael D
Abstract excerpt
Abstract Angiotensin II (AngII), via the AngII type 1 receptor (AT(1)R), contributes to oxidative stress. Aerobic exercise training (AEXT) reduces the risk of cardiovascular (CV) disease, presumably by reducing the grade of oxidative stress. We investigated the independent and combined influence of the AGTR1 A1166C and -825 T/A polymorphisms on oxidative stress and plasma AngII responses to AEXT in pre- and stage...
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