Article
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.
Cancer cell - 7 Jul 2009
McGillicuddy Lauren T, Fromm Jody A, Hollstein Pablo E, Kubek Sara, Beroukhim Rameen, De Raedt Thomas, Johnson Bryan W, Williams Sybil M G, Nghiemphu Phioanh, Liau Linda M, Cloughesy Tim F, Mischel Paul S, Parret Annabel, Seiler Jeanette, Moldenhauer Gerd, Scheffzek Klaus, Stemmer-Rachamimov Anat O, Sawyers Charles L, Brennan Cameron, Messiaen Ludwine, Mellinghoff Ingo K, Cichowski Karen
Abstract excerpt
Loss-of-function mutations in the NF1 tumor suppressor result in deregulated Ras signaling and drive tumorigenesis in the familial cancer syndrome neurofibromatosis type I. However, the extent to which NF1 inactivation promotes sporadic tumorigenesis is unknown. Here we report that NF1 is inactivated in sporadic gliomas via two mechanisms: excessive proteasomal degradation and genetic loss. NF1 protein...
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